Patil Kalpana S, Jalalpure S S, Wadekar R R
Department of Pharmacognosy, K.L.E.S.'s College of Pharmacy, Belgaum-590 010, India.
Indian J Pharm Sci. 2009 Jan;71(1):68-71. doi: 10.4103/0250-474X.51966.
Aqueous extract of roots of Baliospermum montanum was evaluated on preliminary basis for immunomodulatory activity by studying neutrophil phagocytic function. The different concentration of (25, 50, 100 mug/ml) of aqueous extract of roots of Baliospermum montanum was subjected to study its effect on different in vitro methods of phagocytosis such as neutrophil locomotion, chemotaxis, immunostimulant activity of phagocytosis of killed Candida albicans and qualitative nitroblue tetrazolium test by using human neutrophils. This preliminary study revealed that Baliospermum montanum extract has stimulated chemotactic, phagocytic and intracellular killing potency of human neutrophils at the different concentration. From the results obtained it can be observed that the aqueous extract of Baliospermum montanum stimulate cell-mediated immune system by increasing neutrophil function.
通过研究中性粒细胞吞噬功能，初步评估了巴豆树根部水提取物的免疫调节活性。对不同浓度（25、50、100微克/毫升）的巴豆树根部水提取物进行研究，以观察其对不同体外吞噬方法的影响，如中性粒细胞运动、趋化性、杀死白色念珠菌的吞噬免疫刺激活性以及使用人类中性粒细胞进行的定性硝基蓝四氮唑试验。这项初步研究表明，巴豆树提取物在不同浓度下均能刺激人类中性粒细胞的趋化、吞噬和细胞内杀伤能力。从所得结果可以看出，巴豆树水提取物通过增强中性粒细胞功能来刺激细胞介导的免疫系统。
