恒河猴幽门螺杆菌感染的胃转录谱
Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque.
作者信息
Huff Jennifer L, Hansen Lori M, Solnick Jay V
机构信息
Department of Medical Microbiology and Immunology, Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA.
出版信息
Infect Immun. 2004 Sep;72(9):5216-26. doi: 10.1128/IAI.72.9.5216-5226.2004.
Abstract
Infection with Helicobacter pylori is usually asymptomatic but sometimes progresses to peptic ulcer disease or gastric adenocarcinoma. The development of disease involves both host and bacterial factors. In order to better understand host factors in pathogenesis, we studied the gastric transcription profile of H. pylori infection in the rhesus macaque by using DNA microarrays. Significant changes were found in the expression of genes important for innate immunity, chemokines and cytokines, cell growth and differentiation, apoptosis, structural proteins, and signal transduction and transcription factors. This broad transcription profile demonstrated expected up-regulation of cell structural elements and the host inflammatory and immune response, as well as the novel finding of down-regulation of heat shock proteins. These results provide a unique view of acute H. pylori infection in a relevant animal model system and will direct future studies regarding the host response to H. pylori infection.
摘要
幽门螺杆菌感染通常无症状，但有时会发展为消化性溃疡病或胃腺癌。疾病的发展涉及宿主和细菌因素。为了更好地了解发病机制中的宿主因素，我们通过DNA微阵列研究了恒河猴幽门螺杆菌感染的胃转录谱。发现与先天免疫、趋化因子和细胞因子、细胞生长和分化、细胞凋亡、结构蛋白以及信号转导和转录因子相关的重要基因表达有显著变化。这种广泛的转录谱显示了预期的细胞结构成分上调以及宿主炎症和免疫反应，还有热休克蛋白下调这一新发现。这些结果为相关动物模型系统中急性幽门螺杆菌感染提供了独特视角，并将指导未来关于宿主对幽门螺杆菌感染反应的研究。
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