Pitetti K H, Climstein M, Campbell K D, Barrett P J, Jackson J A
College of Health Professions, Wichita State University, KS 67208-1595.
Med Sci Sports Exerc. 1992 Jan;24(1):13-9.
The purpose of this study was to compare the cardiovascular capacities of individuals with Down syndrome (DS) to individuals without Down syndrome who are mentally retarded. Sixteen young adults with DS and 16 individuals without DS (12 males and 4 females, respectively), all with mild/moderate mental retardation, participated in this study. Peak VO2 (absolute and relative), VE (1.min-1), heart rate (HR, b.min-1), and RER (VCO2/VO2) were determined by exercise tests utilizing a treadmill (TM) and Schwinn Air-Dyne ergometer (SAE). The best test result was chosen from the TM and SAE tests and used for statistical comparisons. Cardiac output (Q, 1.min-1) was measured while standing quietly and while walking at 3 mph, 0% grade, using the CO2 rebreathing method for 11 (9 males and 2 females) subjects from each group. Arteriovenous oxygen differences (a-v O2), cardiac index (QI), and stroke volume (SV) were calculated from VO2, Q, HR, and body surface area. Peripheral vascular resistance (PVR), left ventricular work index (LVWI), and left ventricular stroke work index (LVSWI) were calculated from mean arterial pressure, Q, QI, and stroke volume index. Results showed that individuals without DS had statistically significant (P less than 0.01) higher mean peak VO2 (35.6 vs 24.6 ml.kg-1.min-1; 2567 vs 1683 ml.min-1), VE (89.3 vs 59.2 1/min-1), and HR (179 vs 159 b.min-1) than individuals with DS, respectively. No differences in RER were seen between the groups. No differences were seen in cardiovascular parameters measured while quietly standing.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是比较唐氏综合征（DS）患者与智力发育迟缓的非唐氏综合征患者的心血管能力。16名患有DS的年轻成年人和16名非DS患者（分别为12名男性和4名女性），均为轻度/中度智力发育迟缓，参与了本研究。通过使用跑步机（TM）和施温空气动力测力计（SAE）进行运动测试，测定峰值VO2（绝对值和相对值）、VE（升/分钟）、心率（HR，次/分钟）和呼吸交换率（RER，VCO2/VO2）。从TM和SAE测试中选择最佳测试结果用于统计比较。使用二氧化碳重呼吸法，对每组中的11名（9名男性和2名女性）受试者在安静站立和以3英里/小时、坡度为0%行走时测量心输出量（Q，升/分钟）。根据VO2、Q、HR和体表面积计算动静脉氧差（a-v O2）、心脏指数（QI）和每搏输出量（SV）。根据平均动脉压、Q、QI和每搏输出量指数计算外周血管阻力（PVR）、左心室作功指数（LVWI）和左心室每搏作功指数（LVSWI）。结果显示，非DS患者的平均峰值VO2（35.6对24.6毫升·千克-1·分钟-1；2,567对1,683毫升/分钟）、VE（89.3对59.2升/分钟）和HR（179对159次/分钟）在统计学上显著高于DS患者（P小于0.01）。两组之间的RER没有差异。安静站立时测量的心血管参数没有差异。（摘要截断于250字）
