Abe Justin, Rezvan Panteha Hayati, Vogel Benjamin N, Kazerooni Lilia, Lucas Maeve C, Yousuf Mariam M, Silverman Mackenzie, Nagesh Deepti, Jafarpour Saba, Santoro Jonathan D
John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
Biostatistics and Data Management Core, The Saban Research Institute.
J Hypertens. 2025 Oct 1;43(10):1695-1702. doi: 10.1097/HJH.0000000000004107. Epub 2025 Jul 22.
Individuals with Down syndrome (DS) have been reported to have lower systemic blood pressure compared to individuals without DS. This study sought to retrospectively evaluate biomedical parameters in patients with DS undergoing procedural sedation compared to non-DS controls.
A retrospective observational study was performed comparing children and young adults with DS ( n = 150) and age-matched non-DS patients ( n = 146) who underwent procedural sedation. Demographics, comorbidities, and diagnostic studies were assessed, along with preprocedural baseline, median procedural, and procedural nadir systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP). The average rate of change in SBP and DBP from baseline to nadir was also examined between the two groups.
Although baseline SBP, DBP, and PP were comparable between the two groups, individuals with DS showed lower median procedural SBP and DBP ( P < 0.001) as well as lower procedural nadir SBP, DBP, and PP ( P < 0.001). Consistent results were found for median SBP ( P = 0.006) and nadir SBP ( P = 0.006) percentiles. Notably, the reduction from baseline to nadir during sedation was larger in individuals with DS for both SBP (mean difference [95% CI]: -12.3 [-16.1, -8.6]) and DBP (-10.2 [-13.3, -7.0]) compared to the non-DS controls. These differences remained consistent even after adjusting for demographic factors.
Children and young adults with DS exhibited significantly larger blood pressure drops during procedural sedation. Additional research is warranted to investigate the clinical significance of these findings, including the potential for decreased cerebral blood flow in this population during sedation.
据报道，与非唐氏综合征（DS）患者相比，唐氏综合征患者的全身血压较低。本研究旨在回顾性评估接受程序性镇静的DS患者与非DS对照者的生物医学参数。
进行了一项回顾性观察研究，比较接受程序性镇静的DS儿童和青年（n = 150）与年龄匹配的非DS患者（n = 146）。评估了人口统计学、合并症和诊断研究，以及术前基线、术中中位数和术中最低收缩压（SBP）、舒张压（DBP）和脉压（PP）。还比较了两组从基线到最低值时SBP和DBP的平均变化率。
尽管两组之间的基线SBP、DBP和PP相当，但DS患者的术中中位数SBP和DBP较低（P < 0.001），术中最低SBP、DBP和PP也较低（P < 0.001）。中位数SBP（P = 0.006）和最低SBP（P = 0.006）百分位数也得到了一致的结果。值得注意的是，与非DS对照者相比，DS患者在镇静期间从基线到最低值的SBP（平均差异[95%CI]：-12.3[-16.1，-8.6]）和DBP（-10.2[-13.3，-7.0]）下降幅度更大。即使在调整人口统计学因素后，这些差异仍然一致。
DS儿童和青年在程序性镇静期间血压下降幅度明显更大。有必要进行更多研究来调查这些发现的临床意义，包括该人群在镇静期间脑血流量减少的可能性。
