外源细菌延长果蝇寿命
Drosophila lifespan enhancement by exogenous bacteria.
作者信息
Brummel Ted, Ching Alisa, Seroude Laurent, Simon Anne F, Benzer Seymour
机构信息
Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12974-9. doi: 10.1073/pnas.0405207101. Epub 2004 Aug 20.
Abstract
We researched the lifespan of Drosophila under axenic conditions compared with customary procedure. The experiments revealed that the presence of bacteria during the first week of adult life can enhance lifespan, despite unchanged food intake. Later in life, the presence of bacteria can reduce lifespan. Certain long-lived mutants react in different ways, indicating an interplay between bacteria and longevity-enhancing genes.
摘要
我们研究了无菌条件下果蝇的寿命，并与常规方法进行了比较。实验表明，成年后第一周存在细菌可延长寿命，尽管食物摄入量不变。在生命后期，细菌的存在会缩短寿命。某些长寿突变体的反应不同，这表明细菌与长寿增强基因之间存在相互作用。
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