Hosaka Kayo, Ishii Kazunari, Sakamoto Setsu, Sadato Norihiro, Fukuda Hiroshi, Kato Takashi, Sugimura Kazuro, Senda Michio
Department of Radiology, Kobe University, Kobe, Japan.
Eur J Nucl Med Mol Imaging. 2005 Jan;32(1):92-7. doi: 10.1007/s00259-004-1576-z. Epub 2004 Aug 21.
Statistical parametric mapping (SPM) and NEUROSTAT (NS) are widely used for intersubject statistical analysis of brain images. We investigated individual anatomical variations after standardization of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) images of normal brain and compared the differences in the standardized images obtained from SPM and NS.
Twenty healthy normal subjects were recruited for FDG PET and magnetic resonance imaging (MRI) studies. Sylvian fissures (SF), cingulate sulci (CingS) and central sulci (CtlS) were marked on the brain surface of each individual's co-registered MR images. Then spatial standardization was performed on each subject's PET images using SPM99 and NS with NS's FDG template image, and each subject's MR images (with the SF, CingS, and CtlS marked in advance) were standardized using the sets of parameters obtained from PET standardization by SPM and NS, respectively. The coordinates of each subject's SF, CingS, and CtlS detected on the MR images standardized by the two methods were measured and compared with those on the template images.
The mean individual deviations from the averaged coordinates for the markers on the SF, CingS and CtlS standardized by SPM and by NS were no more than 0.21-1.15 mm. The number of voxels within the brain volume on standardized MR images of all 20 subjects was 88.0% of the total number of brain volume voxels for SPM and 85.3% for NS.
This study demonstrates that SPM and NS yield relatively small differences in standardization and that both methods are effective and valid for PET studies in normal subjects.
统计参数映射（SPM）和神经统计学（NS）被广泛用于脑图像的受试者间统计分析。我们研究了正常脑18F-氟脱氧葡萄糖正电子发射断层扫描（FDG PET）图像标准化后的个体解剖变异，并比较了从SPM和NS获得的标准化图像中的差异。
招募20名健康正常受试者进行FDG PET和磁共振成像（MRI）研究。在每个个体的配准后MR图像的脑表面标记外侧裂（SF）、扣带沟（CingS）和中央沟（CtlS）。然后使用SPM99和NS以及NS的FDG模板图像对每个受试者的PET图像进行空间标准化，并且分别使用从SPM和NS的PET标准化获得的参数集对每个受试者的MR图像（预先标记了SF、CingS和CtlS）进行标准化。测量在通过两种方法标准化的MR图像上检测到的每个受试者的SF、CingS和CtlS的坐标，并与模板图像上的坐标进行比较。
通过SPM和NS标准化的SF、CingS和CtlS上标记的平均个体与平均坐标偏差不超过0.21 - 1.15毫米。所有20名受试者的标准化MR图像上脑体积内的体素数量对于SPM是脑体积总体素数量的88.0%，对于NS是85.3%。
本研究表明SPM和NS在标准化方面产生的差异相对较小，并且两种方法对于正常受试者的PET研究都是有效且可靠的。
