Buchwald A B, Werner G S, Unterberg C, Voth E, Kreuzer H, Wiegand V
Department of Cardiology, University Clinic, Göttingen, Federal Republic of Germany.
Am Heart J. 1992 Apr;123(4 Pt 1):878-85. doi: 10.1016/0002-8703(92)90691-n.
In an open clinical study, a xenon-chloride excimer laser was used for angioplasty of coronary stenoses (n = 48) and chronic total occlusions (n = 56) in 104 patients. Multifiber catheters (4.0F to 5.5F) transmitted 37 to 120 mjoules/mm2 of fiber surface. Excimer laser angioplasty was successful in 43 patients with a stenosis (89%), followed by percutaneous transluminal coronary angioplasty in 21 patients (49%) to reduce the stenosis to less than 50% luminal narrowing. In 39 patients (70%) with a chronic occlusion (age 1 to 14 months), recanalization by means of excimer laser angioplasty was successful, with subsequent percutaneous transluminal coronary angioplasty performed in 23 patients. Major complications included one perforation, one acute occlusion, and two severe dissections. Six-month angiographic follow-up examinations after successful angioplasty were completed in 40 patients (98%) with stenoses and 34 (94%) with occlusions. Restenosis (greater than 20% decrease in luminal diameter) occurred in 13 patients (33%) with stenoses and in 16 patients (47%) after angioplasty of a chronic occlusion. These long-term results indicate that restenosis after excimer laser angioplasty of coronary stenoses and chronic total occlusions is similar to reported results of conventional balloon angioplasty.
在一项开放性临床研究中，使用氯化氙准分子激光对104例患者的冠状动脉狭窄（n = 48）和慢性完全闭塞病变（n = 56）进行血管成形术。多光纤导管（4.0F至5.5F）传输的能量为37至120毫焦/平方毫米光纤表面。准分子激光血管成形术使43例狭窄患者（89%）获得成功，随后21例患者（49%）接受经皮腔内冠状动脉血管成形术，将狭窄程度降低至管腔狭窄小于50%。在39例慢性闭塞患者（年龄1至14个月，70%）中，准分子激光血管成形术再通成功，随后23例患者接受经皮腔内冠状动脉血管成形术。主要并发症包括1例穿孔、1例急性闭塞和2例严重夹层。40例（98%）狭窄患者和34例（94%）闭塞患者在血管成形术成功后完成了6个月的血管造影随访检查。13例（33%）狭窄患者和16例（47%）慢性闭塞血管成形术后患者出现再狭窄（管腔直径减小大于20%）。这些长期结果表明，冠状动脉狭窄和慢性完全闭塞的准分子激光血管成形术后再狭窄情况与传统球囊血管成形术的报道结果相似。
