Go Yasuhiro, Rakotoarisoa Gilbert, Kawamoto Yoshi, Shima Taizo, Koyama Naoki, Randrianjafy Albert, Mora Roger, Hirai Hirohisa
Department of Biosystems Science, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa, 240-0193, Japan.
Primates. 2005 Apr;46(2):135-9. doi: 10.1007/s10329-004-0101-0. Epub 2004 Aug 20.
Major histocompatibility complex genes (Mhc-DQB and Mhc-DRB) were sequenced in seven aye-ayes (Daubentonia madagascariecsis), which is an endemic and endangered species in Madagascar. An aye-aye from a north-eastern population showed genetic relatedness to individuals of a north-western population and had a somewhat different repertoire from another north-eastern individual. These observations suggest that the extent of genetic variation in Mhc genes is not excessively small in the aye-aye in spite of recent rapid destruction of their habitat by human activities. In light of Mhc gene evolution, trans-species and allelic polymorphisms can be estimated to have been retained for more than 50 Ma (million years) based on the time scale of lemur evolution.
对马达加斯加的7只指猴（Daubentonia madagascariecsis）进行了主要组织相容性复合体基因（Mhc - DQB和Mhc - DRB）测序，指猴是马达加斯加的一种特有濒危物种。一只来自东北部种群的指猴与西北部种群的个体存在遗传相关性，并且其基因库与另一只东北部个体略有不同。这些观察结果表明，尽管近期人类活动导致指猴栖息地迅速遭到破坏，但指猴Mhc基因的遗传变异程度并非过小。根据狐猴进化的时间尺度，从Mhc基因进化的角度估计，跨物种和等位基因多态性已经保留了超过5000万年。
