Gaur L K, Anderson J
Department of Immunogenetics, Puget Sound Blood Center and Program, Seattle, Wash. 98104.
Exp Clin Immunogenet. 1994;11(1):45-52.
In this report the first description of MHC-DQB homologues in prosimians, the lemurs (Lemur fulvus sanfordi) and galagos (Galago garnetti and G. senegalensis moholi), is presented. In these species the class II alleles are similar to their human counterparts, in that the number and position of substitutions are analogous to the substitutions among various human DQB alleles. Presence of allelic variants for both DQB1 and DQB2 in all three species of prosimians studied suggests that the divergence of DQB1-DQB2 allelic lineages predates the divergence of human and prosimian lineages. The DQB2-like sequences from both species of the Galago seem more distant to human DQB2, and somewhat distant to that of the lemur DQB2 and bear numerous species-specific substitutions. It is not clear whether these DQB2-like alleles belong to a third DQB locus or are a true homologue of the contemporary HLA-DQB2 locus.
在本报告中，首次描述了原猴亚目动物狐猴（Lemur fulvus sanfordi）和婴猴（Galago garnetti及G. senegalensis moholi）中的MHC - DQB同源物。在这些物种中，II类等位基因与其人类对应物相似，因为替换的数量和位置类似于各种人类DQB等位基因之间的替换。在所研究的所有三种原猴亚目动物中均存在DQB1和DQB2的等位基因变体，这表明DQB1 - DQB2等位基因谱系的分化早于人类和原猴亚目动物谱系的分化。婴猴两个物种的DQB2样序列与人类DQB2的距离似乎更远，与狐猴DQB2的距离也有些远，并且有许多物种特异性替换。尚不清楚这些DQB2样等位基因是属于第三个DQB基因座，还是当代HLA - DQB2基因座的真正同源物。
