Zitouni Abdelghani, Boudjella Hadjira, Mathieu Florence, Sabaou Nasserdine, Lebrihi Ahmed
Ecole Nationale Supérieure d'Agronomie de Toulouse, INPT, Laboratoire de Génie Chimique, UMR 5503 (CNRS/INPT/UPS), 1, avenue de l'Agrobiopôle, B.P. 107, F-31 326 Castanet-Tolosan Cedex, France.
J Antibiot (Tokyo). 2004 Jun;57(6):367-72. doi: 10.7164/antibiotics.57.367.
In the course of screening for new antibacterial agents, a new isolate collected from a soil sample of an arid area in south Algeria, produced a red pigment which was shown an antagonistic action against a gram-positive bacterium Bacillus subtilis. The isolate was identified as Saccharothrix sp. and named SA 103. The red pigment, eluted by HPLC on reverse phase C18 column, contained two compounds of an anthracycline antibiotics group. The structure of the major product (2) was characterized as mutactimycin C, and PR (1) was a new member of this group, designated as mutactimycin PR. These compounds showed an antibiotic activity against certain gram-positive bacteria in vitro. This is the first report of mutactimycins production by the genus Saccharothrix.
在筛选新型抗菌剂的过程中，从阿尔及利亚南部干旱地区土壤样本中分离出的一种新菌株产生了一种红色色素，该色素对革兰氏阳性细菌枯草芽孢杆菌具有拮抗作用。该菌株被鉴定为糖丝菌属，并命名为SA 103。通过高效液相色谱在反相C18柱上洗脱的红色色素含有两种蒽环类抗生素化合物。主要产物（2）的结构被鉴定为变构霉素C，而PR（1）是该类别的一个新成员，被命名为变构霉素PR。这些化合物在体外对某些革兰氏阳性细菌显示出抗生素活性。这是关于糖丝菌属产生变构霉素的首次报道。
