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Mutactimycin AP，一种从来自阿塔卡马沙漠的放线菌中分离得到的新 Mutactimycin。

Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert.

机构信息

Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UK.

CFisUC, Department of Physics, University of Coimbra, Rua Larga, 3004-516 Coimbra, Portugal.

出版信息

Molecules. 2022 Oct 24;27(21):7185. doi: 10.3390/molecules27217185.

DOI:10.3390/molecules27217185
PMID:36364011
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9656151/
Abstract

Bacteria belonging to the phylum are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against and .

摘要

属于 门的细菌是抗生素的一个非常好的来源，事实上它们主导着当前的临床抗生素领域。本文报道了 Mutactimycin AP，这是一种从生长在极端干旱的阿塔卡马沙漠中的羽扇豆植物根际中分离出来的放线菌菌株中分离得到的新化合物，属于蒽环类抗生素家族。该化合物的结构特征是通过电喷雾电离-质谱（ESI-MS）和 NMR 光谱与分子建模相结合进行的。该化合物对 ESKAPE 病原体进行了测试，结果表明它对耐甲氧西林金黄色葡萄球菌（MRSA）和与牛乳腺炎相关的五种菌株具有活性，对 和 也具有活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/3ac7f8b5d7f1/molecules-27-07185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/9c01cd6d3f40/molecules-27-07185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/b31cc3e18648/molecules-27-07185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/11eed42161a2/molecules-27-07185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/8629a64779eb/molecules-27-07185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/683a74e2779e/molecules-27-07185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/3ac7f8b5d7f1/molecules-27-07185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/9c01cd6d3f40/molecules-27-07185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/b31cc3e18648/molecules-27-07185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/11eed42161a2/molecules-27-07185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/8629a64779eb/molecules-27-07185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/683a74e2779e/molecules-27-07185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3e/9656151/3ac7f8b5d7f1/molecules-27-07185-g006.jpg

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