Bocci V, Aldinucci C
Department of Physiology, Ozonetherapy Centre, University of Siena, Siena, Italy.
J Biol Regul Homeost Agents. 2004 Jan-Mar;18(1):38-44.
We are proposing to evaluate whether a complementary approach based on cycles of oxygen-ozone autohemotherapy (O3-AHT) already performed in millions of patients, can abate the chronic oxidative stress and improve the quality of life of serious hemoglobinopathic patients. Although a preliminary study has yielded encouraging results, it appears appropriate to perform a controlled, randomized and possibly multicentre clinical trial. The long use of this approach in other pathologies has proved to be very useful and it is hoped that scepticism will not prevail over scientific rationale. Ozone, as any other drug, has an intrinsic toxicity that, in the proposed application, is fully tamed by the blood antioxidant system.
我们提议评估一种基于已在数百万患者中实施的氧-臭氧自血疗法（O3-AHT）周期的补充方法，是否能够减轻严重血红蛋白病患者的慢性氧化应激并改善其生活质量。尽管一项初步研究已取得令人鼓舞的结果，但进行一项对照、随机且可能多中心的临床试验似乎是恰当的。该方法在其他病症中的长期应用已证明非常有用，希望怀疑论不会战胜科学依据。与任何其他药物一样，臭氧具有内在毒性，但在所提议的应用中，它会被血液抗氧化系统完全控制。
