Bocci V
Institute of General Physiology, University of Siena, Italy.
J Biol Regul Homeost Agents. 1996 Apr-Sep;10(2-3):31-53.
The disinfectant activity of ozone is well recognized and ozone is used worldwide for sterilization of water. The use of ozone as a complementary medical approach is less known, because it has mostly been used in an empirical fashion without a rational basis and appropriate controls. In spite of this drawback, the use of judicious and standardized ozone dosages can elicit the formation of ROS acting as natural physiological activators of several biological functions. There is now a reasonable understanding of a few mechanisms of action and, using classical pharmacological concepts, it appears possible to formulate a rationale for optimizing clinical applications. A further exciting development is that ozone, being an oxidizer, can upregulate the intracellular anti-oxidant enzymes eventually inhibiting the constant, life-long oxidative stress responsible for degenerative diseases and aging. Among various routes for the administration of ozone, the autohemotransfusion procedure, consisting in exposing blood to ozone, i.e. to a calculated and brief oxidative stress, appears safe, simple, inexpensive and amenable to be adjusted to different pathological states It is hoped that this review will help to dispel prejudices, to clarify that ozone toxicity can be tamed, to show that ozone can act as a bioregulator and to encourage controlled clinical investigations to evaluate definitely the validity of ozonetherapy.
臭氧的消毒活性已得到广泛认可，在全球范围内被用于水的消毒。臭氧作为一种辅助医学方法的应用则鲜为人知，因为它大多是以经验性方式使用，缺乏合理依据和适当对照。尽管存在这一缺点，但合理且标准化地使用臭氧剂量能够促使活性氧的形成，这些活性氧可作为多种生物学功能的天然生理激活剂。目前，人们对臭氧的一些作用机制已有合理认识，运用经典药理学概念，似乎有可能为优化临床应用制定出合理依据。另一个令人兴奋的进展是，臭氧作为一种氧化剂，能够上调细胞内抗氧化酶，最终抑制导致退行性疾病和衰老的持续终生的氧化应激。在臭氧的各种给药途径中，自血回输程序，即将血液暴露于臭氧中，也就是使其承受经过计算的短暂氧化应激，似乎安全、简单、廉价且可根据不同病理状态进行调整。希望这篇综述有助于消除偏见，阐明臭氧毒性是可以控制的，表明臭氧可作为一种生物调节剂，并鼓励开展对照临床研究以明确评估臭氧疗法的有效性。
