Dobranskyte A, Jugdaohsingh R, Stuchlik E, Powell J J, White K N, McCrohan C R
School of Biological Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Environ Pollut. 2004 Dec;132(3):427-33. doi: 10.1016/j.envpol.2004.05.023.
Aluminium accumulation by the freshwater snail Lymnaea stagnalis is correlated with behavioural depression which is ameliorated by addition of orthosilicic acid. We hypothesised that Si is relocated to the digestive gland in response to Al, leading to the formation of non-toxic hydroxyaluminosilicates (HAS). Exposure to 500 microg l(-1) Al for 30 days was associated with an initial period of behavioural depression, followed by apparent tolerance and subsequent depression, suggesting saturation of the cellular detoxification pathway during prolonged exposure. Exogenous Si (7.77 mg l(-1)) completely ameliorated all behavioural effects of Al but did not prevent its accumulation. In the presence of added Al, significantly more of this Si was accumulated by the tissues, compared to controls and snails exposed to Si alone. In snails exposed to Al plus Si, Al and Si concentrations were significantly correlated, with a ratio around 3:1 Al:Si, consistent with the presence of the non-toxic HAS protoimogolite.
淡水蜗牛椎实螺体内铝的积累与行为抑制相关，而添加原硅酸可改善这种行为抑制。我们推测，硅会响应铝而重新分布到消化腺中，从而导致无毒的羟基铝硅酸盐（HAS）形成。暴露于500微克/升的铝中30天，最初会出现行为抑制期，随后是明显的耐受性，接着又是行为抑制，这表明在长期暴露过程中细胞解毒途径已饱和。外源硅（7.77毫克/升）完全改善了铝对所有行为的影响，但并未阻止铝的积累。与对照组和单独暴露于硅的蜗牛相比，在添加了铝的情况下，组织积累的这种硅明显更多。在暴露于铝加硅的蜗牛中，铝和硅的浓度显著相关，铝与硅的比例约为3:1，这与无毒的HAS原伊莫戈石的存在一致。
