van Krimpen C, Elferink A, Broodman C A, Hop W C J, Pronk A, Menke M
Department of Surgical Pathology, Reinier de Graaf Hospital/Diagnostic Centre SSDZ, P.O. Box 5011, 2600 GA Delft, The Netherlands.
Breast. 2004 Aug;13(4):329-33. doi: 10.1016/j.breast.2003.11.008.
Reports about neuroendocrine (NE) differentiation in breast carcinomas and its possible relation with prognosis are scarce. Furthermore the results of some studies have not been subjected to multivariate survival analysis and the follow-up periods were relatively short. Therefore, in the present long-term follow-up study, the prognostic influence of immunohistochemically defined NE cells, present in the tumours of 40 out of 317 (12.6%) curatively operated breast cancer patients, was studied. The mean follow-up period was 104 months. NE differentiation (NED) was determined by the immunohistochemical detection of chromogranin A and/or synaptophysin. This is concordant with other studies focussing on NED in breast cancer. In contrast to the literature in our series only in 9 out of 40 cases (23%) we were able to detect coexpression of chromogranin A and synaptophysin. This might be due to the characteristics of the antibodies we used. Although most tumours in our series were of the usual type, some tumours with NED were of a special type. Neither univariately, nor taking account of various known prognostic factors, does focal NED appear to carry a special prognostic significance. This finding is in line with results of previous studies.
关于乳腺癌中神经内分泌（NE）分化及其与预后可能关系的报道很少。此外，一些研究结果未进行多因素生存分析，且随访期相对较短。因此，在本长期随访研究中，对317例接受根治性手术的乳腺癌患者中40例（12.6%）肿瘤中免疫组化定义的NE细胞的预后影响进行了研究。平均随访期为104个月。NE分化（NED）通过嗜铬粒蛋白A和/或突触素的免疫组化检测来确定。这与其他关注乳腺癌NED的研究一致。与文献不同的是，在我们的系列中，40例病例中只有9例（23%）能检测到嗜铬粒蛋白A和突触素的共表达。这可能是由于我们使用的抗体的特性。虽然我们系列中的大多数肿瘤是常见类型，但一些有NED的肿瘤是特殊类型。无论是单因素分析，还是考虑各种已知的预后因素，局灶性NED似乎都没有特殊的预后意义。这一发现与先前研究的结果一致。
