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B 细胞慢性淋巴细胞白血病的组织病理学

Histopathology of B-cell chronic lymphocytic leukemia.

作者信息

Pileri Stefano A, Sabattini Elena, Agostinelli Claudio, Bodega Laura, Rossi Maura, Zinzani Pier Luigi, Marafioti Teresa

机构信息

Unit of Haematopathology, Institute of Haematology and Clinical Oncology "L. and A. Seràgnoli", Bologna University, Via Massarenti 9, 40138 Bologna, Italy.

出版信息

Hematol Oncol Clin North Am. 2004 Aug;18(4):807-26, viii. doi: 10.1016/j.hoc.2004.04.010.

DOI:10.1016/j.hoc.2004.04.010
PMID:15325700
Abstract

Histologic and immunohistologic findings of B-cell chronic lymphocytic leukemia/small lymphocytic leukemia are revised in the light of the more recent knowledge on the pathobiology of the disease. The guidelines for the optimal handling of the bioptic samples are provided. The relevance of the examination of trephines and surgical specimens is outlined with special reference to the identification of risk factors in individual patients.

摘要

根据对B细胞慢性淋巴细胞白血病/小淋巴细胞白血病病理生物学的最新认识,对其组织学和免疫组织学发现进行了修订。提供了活检样本最佳处理的指南。概述了骨髓活检组织和手术标本检查的相关性,并特别提及个体患者危险因素的识别。

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Histopathology of B-cell chronic lymphocytic leukemia.B 细胞慢性淋巴细胞白血病的组织病理学
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Bone marrow biopsy in chronic lymphocytic leukemia.慢性淋巴细胞白血病的骨髓活检
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Bone marrow infiltration pattern in B-cell chronic lymphocytic leukemia is related to immunoglobulin heavy-chain variable region mutation status and expression of 70-kd zeta-associated protein (ZAP-70).B细胞慢性淋巴细胞白血病的骨髓浸润模式与免疫球蛋白重链可变区突变状态及70-kd ζ相关蛋白(ZAP-70)的表达有关。
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[The significance of histopathology of bone marrow for the life expectancy of patients with chronic lymphatic leukemia].[骨髓组织病理学对慢性淋巴细胞白血病患者预期寿命的意义]
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[Description of a clonal T cell population in peripheral blood and bone marrow from a patient with B lymphocytic lymphoma].[一名B淋巴细胞淋巴瘤患者外周血和骨髓中克隆性T细胞群体的描述]
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[Which cells in the differentiation process become precursors of B-cell chronic lymphoid leukemia?].
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In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow.稳定型慢性淋巴细胞白血病的体内动力学与体细胞超突变水平呈负相关,提示骨髓中无主要的白血病细胞更新。
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B cell chronic lymphocytic leukaemia/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens.B细胞慢性淋巴细胞白血病/小淋巴细胞淋巴瘤:ZAP70检测在骨髓活检标本中的作用
J Clin Pathol. 2007 Jun;60(6):627-32. doi: 10.1136/jcp.2006.039586. Epub 2006 Aug 17.
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Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells.
环氧化酶-2在B慢性淋巴细胞白血病细胞中过表达的潜在致病意义。
Am J Pathol. 2005 Dec;167(6):1599-607. doi: 10.1016/S0002-9440(10)61244-8.