Sharoni Yoav, Danilenko Michael, Dubi Noga, Ben-Dor Anat, Levy Joseph
Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka Medical Center of Kupat Holim, Beer-Sheva, Israel.
Arch Biochem Biophys. 2004 Oct 1;430(1):89-96. doi: 10.1016/j.abb.2004.03.009.
The possible involvement of several transcription systems in the anticancer activity of carotenoids is the focus of this review. Carotenoids modulate the basic mechanisms of cell proliferation, growth factor signaling, gap junctional intercellular communication, and produce changes in the expression of many proteins participating in these processes. The changes in the expression of multiple proteins suggest that the initial effect of carotenoids involves modulation of transcription. We and others have found evidence for the role of several transcription systems, such as the retinoid receptors, activator protein-1 (AP-1), peroxisome proliferator-activated receptors (PPAR), xenobiotic receptors and the antioxidant response element (ARE), in the anticancer activity of carotenoids. The observed modulation of a network of transcription systems may provide the molecular basis for the synergistic anticancer effects of the combinations of various carotenoids together with other dietary and pharmacologic compounds.
几种转录系统可能参与类胡萝卜素的抗癌活性是本综述的重点。类胡萝卜素调节细胞增殖、生长因子信号传导、间隙连接细胞间通讯的基本机制，并使参与这些过程的许多蛋白质的表达发生变化。多种蛋白质表达的变化表明类胡萝卜素的初始作用涉及转录调节。我们和其他人已经发现几种转录系统，如视黄酸受体、活化蛋白-1（AP-1）、过氧化物酶体增殖物激活受体（PPAR）、外源性受体和抗氧化反应元件（ARE）在类胡萝卜素抗癌活性中的作用证据。观察到的转录系统网络调节可能为各种类胡萝卜素与其他饮食和药物化合物组合的协同抗癌作用提供分子基础。
