Mooradian A D
Department of Internal Medicine, St. Louis University School of Medicine.
Oncology (Williston Park). 1992 Feb;6(2 Suppl):39-44.
The rate of aging is not uniform among all individuals. Thus, determination of the biological age of an individual and possibly the biological age of his or her organ systems poses a special challenge to the gerontologist. This could be accomplished if specific biomarkers of aging were available, which would allow standardization of studies, help us understand the various determinants of aging, monitor the impact of various interventions on the rate of aging, and possible allow estimates of life expectancy and predictions of future morbidity. Specific criteria need to be developed for accepting a parameter as a biomarker of aging, since an age-related alteration in a biological parameter does not necessarily qualify. Potential biomarkers of human aging include in vitro proliferative capacity of fibroblasts, glycation of collagen, and DNA unwinding rate.
衰老速度在所有个体中并不一致。因此，确定个体的生物学年龄以及其器官系统可能的生物学年龄，对老年医学专家来说是一项特殊挑战。如果能找到特定的衰老生物标志物，就能实现这一点，这将使研究标准化，帮助我们理解衰老的各种决定因素，监测各种干预措施对衰老速度的影响，并有可能估算预期寿命和预测未来发病率。由于生物学参数中与年龄相关的变化不一定符合要求，因此需要制定特定标准来将一个参数认定为衰老生物标志物。人类衰老的潜在生物标志物包括成纤维细胞的体外增殖能力、胶原蛋白的糖基化以及DNA解旋速率。
