Mooradian A D
Division of Restorative Medicine, University of Arizona College of Medicine.
J Gerontol. 1990 Nov;45(6):B183-6. doi: 10.1093/geronj/45.6.b183.
The identification of specific biomarkers of aging would be an important milestone in gerontologic research. In this communication, the goals of identifying biomarkers of aging are summarized and some criteria for defining biomarkers are suggested. An age-related alteration in a biological parameter is not necessarily a biomarker of aging. None of the previously observed age-related changes satisfies all the criteria. Potential biomarkers that are applicable to human aging include in vitro proliferative capacity of fibroblasts, glycation of collagen, and DNA unwinding rate. Future research should focus on identifying age-related changes that are not merely expressions of aging, but also have some causal link to aging.
确定衰老的特定生物标志物将是老年学研究中的一个重要里程碑。在本交流中，总结了确定衰老生物标志物的目标，并提出了一些定义生物标志物的标准。生物参数中与年龄相关的变化不一定是衰老的生物标志物。以前观察到的与年龄相关的变化均未满足所有标准。适用于人类衰老的潜在生物标志物包括成纤维细胞的体外增殖能力、胶原蛋白的糖基化以及DNA解旋速率。未来的研究应侧重于识别那些不仅是衰老表现，而且与衰老有某种因果关系的与年龄相关的变化。
