Tréton J A, Courtois Y
Association Claude-Bernard, Unité de Recherches Gérontologiques, INSERM U 118, Paris.
Ann Biol Clin (Paris). 1990;48(5):319-22.
This paper summarises a conceptual discussion of some aspects of biomarkers of aging and the logical strategy for developing them. A biomarker of aging is a biological parameter of an organism that either alone or in some multivariate composite will, in the absence of disease, better predict functional capability at some late age than with chronological age. The criteria for putative biomarker measurement and assessment of putative biomarkers are discussed.
本文总结了关于衰老生物标志物某些方面的概念性讨论以及开发这些标志物的逻辑策略。衰老生物标志物是生物体的一个生物学参数，在没有疾病的情况下，该参数单独或与其他多元组合相比，能比按时间计算的年龄更好地预测某个晚年的功能能力。文中讨论了假定生物标志物测量的标准以及对假定生物标志物的评估。
