Serafini Mauro, Del Rio Daniele
Antioxidant Research Laboratory, Unit of Human Nutrition, National Institute for Food and Nutrition Research, Rome, Italy.
Redox Rep. 2004;9(3):145-52. doi: 10.1179/135100004225004814.
Total Antioxidant Capacity (TAC) considers the cumulative action of all the antioxidants present in plasma and body fluids, thus providing an integrated parameter rather than the simple sum of measurable antioxidants. The capacity of known and unknown antioxidants and their synergistic interaction is, therefore, assessed, thus giving an insight into the delicate balance in vivo between oxidants and antioxidants. There is new evidence indicating the importance of understanding the mechanisms of the homeostatic control of TAC in plasma and tissues and its modification during oxidative stress development. Recently, the epidemiological application of TAC has been proposed as a new tool for investigating the relationship between dietary antioxidants and cancer risk in population studies. This review outlines the pros and cons of the more common assays for measuring plasma TAC and the latest findings on dietary modulation of plasma redox status. Finally, the feasibility of the 'TAC concept' as an innovative tool for investigating the association between diet and oxidative stress is discussed.
总抗氧化能力（TAC）考虑了血浆和体液中所有抗氧化剂的累积作用，因此提供的是一个综合参数，而非可测量抗氧化剂的简单总和。因此，已知和未知抗氧化剂的能力及其协同相互作用得以评估，从而深入了解体内氧化剂与抗氧化剂之间的微妙平衡。有新证据表明，了解血浆和组织中TAC稳态控制机制及其在氧化应激发展过程中的变化具有重要意义。最近，TAC的流行病学应用已被提议作为在人群研究中调查膳食抗氧化剂与癌症风险之间关系的一种新工具。本综述概述了测量血浆TAC的更常见检测方法的优缺点以及膳食调节血浆氧化还原状态的最新研究结果。最后，讨论了“TAC概念”作为研究饮食与氧化应激之间关联的创新工具的可行性。
