Pan Hong, Lin Shasha
Department of Neurology, Deqing People's Hospital, Huzhou, China.
Department of Ultrasound, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Front Nutr. 2024 Sep 19;11:1450815. doi: 10.3389/fnut.2024.1450815. eCollection 2024.
In this study, we aim to examine the impact of dietary total antioxidant capacity (TAC) on sleep problems and depressive symptoms (DS); besides, we seek to elucidate the potential mediating effect of dietary TAC on the relationships between sleep problems and DS.
Weighted Kruskal-Wallis tests for continuous variables and Chi-square tests for categorical variables were employed to discriminate between DS and non-DS participants. Multivariable logistic regression and restricted cubic spline analysis were applied to evaluate the associations of TAC with DS and sleep problems.
Among the 21,805 participants, 1,947 participants suffered from DS. Weighted multivariable logistical regression indicated that shorter sleep hours were linked to an increased likelihood of risk of DS even after complete adjustments. Restricted cubic spline cure displayed that TAC was almost non-linearly correlated with DS and sleep problems. Mediation analysis indicated that sleep duration slightly mediated the association between TAC and DS (proportion of mediation: 3.12%, < 0.001).
This study illustrated the inverse association between TAC value and sleep problems and DS. Furthermore, TAC slightly mediated the effect of sleep duration on the DS, and there was a nearly non-linear relationship between TAC and DS, and TAC and sleep problems.
在本研究中，我们旨在探讨膳食总抗氧化能力（TAC）对睡眠问题和抑郁症状（DS）的影响；此外，我们试图阐明膳食TAC在睡眠问题与DS之间关系中的潜在中介作用。
采用连续变量的加权Kruskal-Wallis检验和分类变量的卡方检验来区分DS参与者和非DS参与者。应用多变量逻辑回归和受限立方样条分析来评估TAC与DS及睡眠问题之间的关联。
在21,805名参与者中，1,947名参与者患有DS。加权多变量逻辑回归表明，即使在进行完全调整后，较短的睡眠时间仍与DS风险增加相关。受限立方样条曲线显示，TAC与DS及睡眠问题几乎呈非线性相关。中介分析表明，睡眠时间对TAC与DS之间的关联有轻微中介作用（中介比例：3.12%，P<0.001）。
本研究表明TAC值与睡眠问题和DS呈负相关。此外，TAC对睡眠时间对DS的影响有轻微中介作用，且TAC与DS以及TAC与睡眠问题之间存在近乎非线性的关系。
