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重症监护病房患者分离出的铜绿假单胞菌中高突变与抗生素耐药性发展之间无关联。

Lack of association between hypermutation and antibiotic resistance development in Pseudomonas aeruginosa isolates from intensive care unit patients.

作者信息

Gutiérrez Olivia, Juan Carlos, Pérez José L, Oliver Antonio

机构信息

Servicio de Microbiología, Hospital Son Dureta, C. Andrea Doria No. 55, 07014 Palma de Mallorca, Spain.

出版信息

Antimicrob Agents Chemother. 2004 Sep;48(9):3573-5. doi: 10.1128/AAC.48.9.3573-3575.2004.

DOI:10.1128/AAC.48.9.3573-3575.2004
PMID:15328130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC514756/
Abstract

Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational antibiotic resistance development is a frequent outcome, the prevalence of hypermutable strains is low (found in isolates from only 1 of 103 patients) and there is no evidence of coselection of the hypermutable and antibiotic resistance phenotypes.

摘要

高突变是从慢性感染的囊性纤维化患者中分离出的铜绿假单胞菌菌株的一个常见特征，这与抗生素耐药性的产生有关。在这项研究中，我们使用了大量来自重症监护病房患者的铜绿假单胞菌连续分离株，发现尽管突变导致抗生素耐药性的产生是一个常见结果，但高突变菌株的流行率很低（在103名患者中仅1名患者的分离株中发现），并且没有证据表明高突变表型和抗生素耐药表型存在共选择现象。

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