用于检测肺炎衣原体大环内酯耐药性的基于基因和培养的方法。
Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae.
作者信息
Riska Paul F, Kutlin Andrei, Ajiboye Patrick, Cua Arnold, Roblin Patricia M, Hammerschlag Margaret R
机构信息
Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
出版信息
Antimicrob Agents Chemother. 2004 Sep;48(9):3586-90. doi: 10.1128/AAC.48.9.3586-3590.2004.
Abstract
Three clinical Chlamydia pneumoniae isolates for which the MIC of azithromycin increased after treatment were investigated for genetic evidence of macrolide resistance. Attempts to induce antibiotic resistance in vitro were made. No genetic mechanism was identified for the phenotypic change in these C. pneumoniae isolates. No macrolide resistance was obtained in vitro.
摘要
对3株经治疗后阿奇霉素最低抑菌浓度（MIC）升高的肺炎衣原体临床分离株进行了大环内酯类耐药的遗传学证据研究。尝试在体外诱导抗生素耐药性。未发现这些肺炎衣原体分离株表型变化的遗传机制。在体外未获得大环内酯类耐药性。
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