衣原体中的抗生素耐药性。
Antibiotic resistance in Chlamydiae.
机构信息
Department of Biomedical Sciences, Oregon State University, Corvallis, 97331-4804, USA.
出版信息
Future Microbiol. 2010 Sep;5(9):1427-42. doi: 10.2217/fmb.10.96.
There are few documented reports of antibiotic resistance in Chlamydia and no examples of natural and stable antibiotic resistance in strains collected from humans. While there are several reports of clinical isolates exhibiting resistance to antibiotics, these strains either lost their resistance phenotype in vitro, or lost viability altogether. Differences in procedures for chlamydial culture in the laboratory, low recovery rates of clinical isolates and the unknown significance of heterotypic resistance observed in culture may interfere with the recognition and interpretation of antibiotic resistance. Although antibiotic resistance has not emerged in chlamydiae pathogenic to humans, several lines of evidence suggest they are capable of expressing significant resistant phenotypes. The adept ability of chlamydiae to evolve to antibiotic resistance in vitro is demonstrated by contemporary examples of mutagenesis, recombination and genetic transformation. The isolation of tetracycline-resistant Chlamydia suis strains from pigs also emphasizes their adaptive ability to acquire antibiotic resistance genes when exposed to significant selective pressure.
有关衣原体的抗生素耐药性的文献报道较少，从人类中采集的菌株也没有自然和稳定的抗生素耐药性的例子。虽然有几例临床分离株对抗生素表现出耐药性的报道，但这些菌株要么在体外失去了耐药表型，要么完全失去了活力。实验室中衣原体培养的程序差异、临床分离株的低回收率以及在培养中观察到的异型耐药的未知意义，可能会干扰对抗生素耐药性的识别和解释。虽然对人类致病的衣原体尚未出现抗生素耐药性，但有几条证据表明它们有能力表达明显的耐药表型。衣原体在体外对抗生素产生耐药性的能力可以通过当代的诱变、重组和遗传转化的例子来证明。从猪中分离出的四环素耐药的猪衣原体菌株也强调了它们在受到显著选择压力时获得抗生素耐药基因的适应能力。
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