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沙眼衣原体23S rRNA基因中的突变与对大环内酯类药物的耐药性相关。

Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides.

作者信息

Misyurina O Y, Chipitsyna E V, Finashutina Y P, Lazarev V N, Akopian T A, Savicheva A M, Govorun V M

机构信息

Research Institute of Physico-Chemical Medicine, Russian Federation Ministry of Health, Moscow, Russia.

出版信息

Antimicrob Agents Chemother. 2004 Apr;48(4):1347-9. doi: 10.1128/AAC.48.4.1347-1349.2004.

DOI:10.1128/AAC.48.4.1347-1349.2004
PMID:15047540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375314/
Abstract

For six clinical isolates of Chlamydia trachomatis, in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C (Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populations of bacteria that did and did not carry 23S rRNA gene mutations.

摘要

对于六株沙眼衣原体临床分离株，已测定了它们对红霉素、阿奇霉素和交沙霉素的体外敏感性。四株分离株对所有抗生素均耐药，且在23S rRNA基因中存在A2058C和T2611C（大肠杆菌编号）突变。所有分离株都有携带和不携带23S rRNA基因突变的细菌混合群体。

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