对在肯尼亚四个不同地理区域获得的恶性疟原虫分离株进行药物敏感性和基因评估。
Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya.
作者信息
Mbaisi Abigael, Liyala Pamela, Eyase Fredrick, Achilla Rachel, Akala Hosea, Wangui Julia, Mwangi Josphat, Osuna Finnley, Alam Uzma, Smoak Bonnie L, Davis Jon M, Kyle Dennis E, Coldren Rodney L, Mason Carl, Waters Norman C
机构信息
U.S. Army Medical Research Unit, Nairobi, Kenya.
出版信息
Antimicrob Agents Chemother. 2004 Sep;48(9):3598-601. doi: 10.1128/AAC.48.9.3598-3601.2004.
Abstract
The drug resistance profiles of Plasmodium falciparum isolated from four regions in Kenya were analyzed for drug resistance profiles. We observed variability in resistance to a broad range of antimalarial drugs across Kenya as determined from in vitro drug susceptibility screening and genotyping analysis.
摘要
对从肯尼亚四个地区分离出的恶性疟原虫的耐药性谱进行了分析。通过体外药物敏感性筛选和基因分型分析，我们观察到肯尼亚各地对多种抗疟药物的耐药性存在差异。
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