二价阳离子化合物对阴道毛滴虫的活性。
Activities of dicationic compounds against Trichomonas vaginalis.
作者信息
Crowell Andrea L, Stephens Chad E, Kumar Arvind, Boykin David W, Secor W Evan
机构信息
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Services, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724, USA.
出版信息
Antimicrob Agents Chemother. 2004 Sep;48(9):3602-5. doi: 10.1128/AAC.48.9.3602-3605.2004.
Abstract
We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 microM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.
摘要
我们评估了44种新型阳离子化合物对甲硝唑敏感和耐药的阴道毛滴虫分离株的活性。三种不同结构类别的六种化合物对敏感和耐药分离株均表现出低至1微摩尔的50%抑制浓度，这表明其作用方式独立于赋予对5-硝基咪唑耐药性的寄生虫生化途径。
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