体外甲硝唑和替硝唑对甲硝唑耐药阴道毛滴虫菌株的活性。
In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.
作者信息
Crowell Andrea L, Sanders-Lewis Kolby A, Secor W Evan
机构信息
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
出版信息
Antimicrob Agents Chemother. 2003 Apr;47(4):1407-9. doi: 10.1128/AAC.47.4.1407-1409.2003.
The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.
比较了替硝唑和甲硝唑对临床分离的耐甲硝唑阴道毛滴虫的体外活性。替硝唑的最低致死浓度（MLC）显著低于甲硝唑的MLC。甲硝唑耐药性增加与替硝唑耐药性增加相关。这些数据支持替硝唑在滴虫病治疗中的作用。
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