Randall Otelio S, Retta Tamrat M, Kwagyan John, Gordeuk Victor R, Xu Shichen, Maqbool Abid R, Ketete Muluemebet, Obisesan Thomas O
Department of Medicine, Howard University, Washington, DC 20060, USA.
Ethn Dis. 2004 Summer;14(3):384-8.
The prevalence of the cardiovascular disease risk factors, dyslipidemia, hypertension, and diabetes mellitus, is increased in the setting of obesity.
To determine whether the prevalence of these risk factors increases with increasing body mass index in an obese cohort, or whether there is a threshold for their appearance.
Individuals with body mass index > or = 30 kg/m2 joined a weight reduction program in the Howard University General Clinical Research Center.
Five hundred fifteen African Americans (aged 12-74 years, mean body mass index of 42.8 +/- 8.5 kg/m2).
The cohort was divided by incremental increases in body mass index of 4.99 kg/m2, and the prevalence rates of hypertension (blood pressure > or = 140/90 mm Hg), dyslipidemia (total cholesterol > 200 mg/dL, or low-density lipoprotein > 130 mg/dL, or elevated ratio of total or low-density to high-density lipoprotein cholesterol) and diabetes mellitus (fasting blood glucose > or = 126 mg/dL or random blood glucose > 200 mg/dL) were determined for each group.
The cohort prevalence rates were: dyslipidemia, 27.0%; hypertension, 56.9%; and diabetes mellitus, 24.1%. These rates are higher than those found in the African-American population by the third National Health and Nutrition Examination Survey. After adjusting for age and sex, there were no significant differences in the prevalence rates of these risk factors according to increasing body mass index, suggesting a threshold of between 30 kg/m2-34.99 kg/m2 for maximal appearance of these risk factors.
The incidence rates of dyslipidemia, hypertension, and diabetes mellitus do not increase with a greater degree of obesity above a body mass index of 34.99 kg/m2.
在肥胖情况下，心血管疾病危险因素、血脂异常、高血压和糖尿病的患病率会升高。
确定在肥胖队列中这些危险因素的患病率是否随体重指数增加而升高，或者它们的出现是否存在一个阈值。
体重指数≥30kg/m²的个体参加了霍华德大学综合临床研究中心的一项减肥计划。
515名非裔美国人（年龄12 - 74岁，平均体重指数为42.8±8.5kg/m²）。
该队列按体重指数以4.99kg/m²的增量进行划分，确定每组高血压（血压≥140/90mmHg）、血脂异常（总胆固醇>200mg/dL，或低密度脂蛋白>130mg/dL，或总胆固醇或低密度脂蛋白与高密度脂蛋白胆固醇的比值升高）和糖尿病（空腹血糖≥126mg/dL或随机血糖>200mg/dL）的患病率。
该队列的患病率分别为：血脂异常27.0%；高血压56.9%；糖尿病24.1%。这些患病率高于第三次全国健康和营养检查调查在非裔美国人群中发现的患病率。在调整年龄和性别后，这些危险因素的患病率根据体重指数增加无显著差异，表明这些危险因素最大出现率的阈值在30kg/m² - 34.99kg/m²之间。
体重指数高于34.99kg/m²时，血脂异常、高血压和糖尿病的发病率不会随着肥胖程度增加而升高。
