Cercato Cintia, Mancini Márcio Corrêa, Arguello Ana Maria Carvalho, Passos Vanessa Quintas, Villares Sandra Mara Ferreira, Halpern Alfredo
Obesity and Metabolic Diseases Group, Department of Endocrinology and Metabology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Rev Hosp Clin Fac Med Sao Paulo. 2004 Jun;59(3):113-8. doi: 10.1590/s0041-87812004000300004. Epub 2004 Jul 28.
To determine the prevalence of systemic hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia in a Brazilian population in relation to body mass index.
Retrospective evaluation of 1213 adults (mean age: 45.2 +/- 12.8; 80.6% females) divided into groups according to body mass index [normal (18.5 - 24.4 kg/m2); overweight (25 - 29.9 kg/m2); grade 1 obesity (30 - 34.9 kg/m2); grade 2 obesity (35 - 39.9 kg/m2), and grade 3 obesity (> or = 40 kg/m2)]. The prevalence of hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia were analyzed in each group. The severity of cardiovascular risk was determined. High-risk patients were considered those reporting 2 or more of the following factors: systemic hypertension, HDL < or = 35 mg/dL, total cholesterol > or = 240 mg/dL, triglycerides > or = 200 mg/dL when HDL < or = 35 mg/dL, and glycemia > or = 126 mg/dL. Moderate-risk patients were those reporting 2 or more of the following factors: systemic hypertension, HDL < or = 45, triglycerides > or = 200 mg/dL, and total cholesterol > or = 200 mg/dL.
The prevalence of systemic hypertension, diabetes mellitus, hypertriglyceridemia, and low HDL-cholesterol levels increased along with weight, but the prevalence of hypercholesterolemia did not. The odds ratio adjusted for gender and age, according to grade of obesity compared with patients with normal weight were respectively 5.9, 8.6, and 14.8 for systemic hypertension, 3.8, 5.8, and 9.2 for diabetes mellitus and 1.2, 1.3, and 2.6 for hypertriglyceridemia. We also verified that body mass index was positively related to cardiovascular high risk (P < .001)
In our population, cardiovascular risk increased along with body mass index.
确定巴西人群中系统性高血压、糖尿病、高胆固醇血症和高甘油三酯血症与体重指数的相关性。
对1213名成年人（平均年龄：45.2±12.8岁；女性占80.6%）进行回顾性评估，根据体重指数将其分为不同组[正常（18.5 - 24.4kg/m²）；超重（25 - 29.9kg/m²）；1级肥胖（30 - 34.9kg/m²）；2级肥胖（35 - 39.9kg/m²），以及3级肥胖（≥40kg/m²）]。分析每组中高血压、糖尿病、高胆固醇血症和高甘油三酯血症的患病率。确定心血管风险的严重程度。高危患者被定义为报告以下2种或更多因素的患者：系统性高血压、高密度脂蛋白（HDL）≤35mg/dL、总胆固醇≥240mg/dL、当高密度脂蛋白≤35mg/dL时甘油三酯≥200mg/dL，以及血糖≥126mg/dL。中危患者为报告以下2种或更多因素的患者：系统性高血压、高密度脂蛋白≤45、甘油三酯≥200mg/dL，以及总胆固醇≥200mg/dL。
系统性高血压、糖尿病、高甘油三酯血症和低高密度脂蛋白胆固醇水平的患病率随体重增加而升高，但高胆固醇血症的患病率未升高。根据肥胖等级，与正常体重患者相比，经性别和年龄调整后的系统性高血压优势比分别为5.9、8.6和14.8，糖尿病为3.8、5.8和9.2，高甘油三酯血症为1.2、1.3和2.6。我们还证实体重指数与心血管高危呈正相关（P < 0.001）
在我们的人群中，心血管风险随体重指数增加而升高。
