Holownia P, Owen E J, Conway G S, Round J, Honour J W
Cobbold Laboratories, University College and Middlesex School of Medicine, London, England.
J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):875-80. doi: 10.1016/0960-0760(92)90441-k.
In a longitudinal study of 82 children we found a gradual rise in median plasma concentrations of 11 beta-hydroxyandrostenedione (11 beta-OH-A4) from 2.5 to 6.4 nmol/l during childhood which was similar in both sexes. This could reflect changes in adrenal function during the adrenarche and sexual maturation. Plasma concentrations of 11 beta-OH-A4 in adults follow the patterns of cortisol secretion. In patients with diseases of the adrenal cortex, the plasma concentrations of 11 beta-OH-A4 were consistent with the pathology of each condition. In women with polycystic ovaries (PCO) undergoing gonadotrophic stimulation for in vitro fertilization and embryo transfer, 11 beta-OH-A4 (median = 3.8 nmol/l), testosterone and androstenedione, were raised when compared to women with normal ovaries (11 beta-OH-A4 median = 2.6 nmol/l). Follicular fluid has concentrations of 11 beta-OH-A4 six to twelve times greater than plasma levels and in women with PCO, 11 beta-OH-A4 concentrations were lower than in women with normal ovaries, which is consistent with an inhibition of ovarian 11 beta-hydroxylase. Granulosa cells in vitro demonstrated the production of 11 beta-OH-A4 by side chain cleavage of cortisol. These data support an adrenal source for 11 beta-OH-A4 but the raised plasma concentrations in women with polycystic ovary syndrome (PCOS) may reflect the excess androgen output from the ovary. 11 beta-OH-A4 may therefore be an additional marker for ovarian dysfunction.
在一项对82名儿童的纵向研究中，我们发现儿童期血浆中11β-羟基雄烯二酮（11β-OH-A4）的中位数浓度从2.5纳摩尔/升逐渐升至6.4纳摩尔/升，男女情况相似。这可能反映了肾上腺功能初现和性成熟过程中肾上腺功能的变化。成年人血浆中11β-OH-A4的浓度遵循皮质醇分泌模式。在肾上腺皮质疾病患者中，11β-OH-A4的血浆浓度与每种疾病的病理情况相符。在接受促性腺激素刺激以进行体外受精和胚胎移植的多囊卵巢（PCO）女性中，与卵巢正常的女性相比，11β-OH-A4（中位数 = 3.8纳摩尔/升）、睾酮和雄烯二酮水平升高（11β-OH-A4中位数 = 2.6纳摩尔/升）。卵泡液中11β-OH-A4的浓度比血浆水平高6至12倍，在PCO女性中，11β-OH-A4浓度低于卵巢正常的女性，这与卵巢11β-羟化酶受到抑制一致。体外培养的颗粒细胞显示可通过皮质醇的侧链裂解产生11β-OH-A4。这些数据支持11β-OH-A4来源于肾上腺，但多囊卵巢综合征（PCOS）女性血浆浓度升高可能反映了卵巢雄激素分泌过多。因此，11β-OH-A4可能是卵巢功能障碍的一个额外标志物。
