Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Horm Res Paediatr. 2018;89(5):284-291. doi: 10.1159/000486036. Epub 2018 May 9.
The 11-oxyandrogens, particularly 11-ketotestosterone, have been recognized as a biologically important gonadal androgen in teleost (bony) fishes for decades, and their presence in human beings has been known but poorly understood. Today, we recognize that 11-oxyandrogens derive from the human adrenal glands and are major bioactive androgens, particularly in women and children. This article will review their biosynthesis and metabolism, abundance in normal and pathologic states, and potential as biomarkers of adrenal developmental changes and disease. Specifically, 11-oxyandrogens are the dominant active androgens in many patients with 21-hydroxylase deficiency.
几十年来，11-氧基雄激素，特别是 11-酮睾酮，已被认为是硬骨鱼类（鱼类）中一种重要的生物活性性腺激素，其在人类中的存在虽然已知但了解甚少。如今，我们认识到 11-氧基雄激素源自人类肾上腺，是主要的生物活性雄激素，特别是在女性和儿童中。本文将综述其生物合成和代谢、在正常和病理状态下的丰度，以及作为肾上腺发育变化和疾病生物标志物的潜力。具体而言，11-氧基雄激素是 21-羟化酶缺乏症许多患者中主要的活性雄激素。
