Nevin K G, Rajamohan T
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695 581, India.
Clin Biochem. 2004 Sep;37(9):830-5. doi: 10.1016/j.clinbiochem.2004.04.010.
The present study was conducted to investigate the effect of consumption of virgin coconut oil (VCO) on various lipid parameters in comparison with copra oil (CO). In addition, the preventive effect of polyphenol fraction (PF) from test oils on copper induced oxidation of LDL and carbonyl formation was also studied.
After 45 days of oil feeding to Sprague-Dawley rats, several lipid parameters and lipoprotein levels were determined. PF was isolated from the oils and its effect on in vitro LDL oxidation was assessed.
VCO obtained by wet process has a beneficial effect in lowering lipid components compared to CO. It reduced total cholesterol, triglycerides, phospholipids, LDL, and VLDL cholesterol levels and increased HDL cholesterol in serum and tissues. The PF of virgin coconut oil was also found to be capable of preventing in vitro LDL oxidation with reduced carbonyl formation.
The results demonstrated the potential beneficiary effect of virgin coconut oil in lowering lipid levels in serum and tissues and LDL oxidation by physiological oxidants. This property of VCO may be attributed to the biologically active polyphenol components present in the oil.
本研究旨在调查与椰干油（CO）相比，食用初榨椰子油（VCO）对各种脂质参数的影响。此外，还研究了测试油中的多酚组分（PF）对铜诱导的低密度脂蛋白（LDL）氧化和羰基形成的预防作用。
给斯普拉格-道利大鼠喂食油45天后，测定了几种脂质参数和脂蛋白水平。从油中分离出PF，并评估其对体外LDL氧化的影响。
与CO相比，通过湿法获得的VCO在降低脂质成分方面具有有益作用。它降低了血清和组织中的总胆固醇、甘油三酯、磷脂、LDL和极低密度脂蛋白（VLDL）胆固醇水平，并提高了高密度脂蛋白（HDL）胆固醇水平。还发现初榨椰子油的PF能够防止体外LDL氧化，并减少羰基形成。
结果表明初榨椰子油在降低血清和组织中的脂质水平以及生理氧化剂诱导的LDL氧化方面具有潜在的有益作用。VCO的这种特性可能归因于油中存在的生物活性多酚成分。
