Tanaka T, Aizawa T, Kato K, Hosoi H
Kaku Igaku. 1992 Feb;29(2):213-20.
PYP SPECT images were underwent in 15 patients with acute myocardial infarction 2-5 times in three weeks. PYP SPECT images were reconstructed as to include both vertebral images and myocardial images. Quantitative estimation of PYP images was performed by the ratio of maximal PYP myocardial uptake to maximal PYP vertebral uptake in the central sagittal images (%PYP). Disappearance of PYP images was defined as the day, when %PYP reached 50%. Normalization of serum myosin light chain I (LCI) level was defined as the day, when LCI level reached 2.5 ng/ml. %PYP decreased continuously and maximal PYP point remained at the same area. Shape of PYP images varied and diminished. In case of anterior wall infarction apical PYP uptake persisted longer than basal uptake. In case of inferior wall infarction basal PYP uptake persisted longer than apical uptake. The mean period from onset to the disappearance of PYP images was 9 +/- 3 days. Pattern of serial serum MB level was simple, however corresponding pattern of serial serum LCI level showed various types. The mean period from onset to the peak level was 4.1 +/- 1 day. Normalization of LCI level was 9.3 +/- 2.9 days. It showed that process of destruction of necrotic myocardium vary in each case. Weak relation was noted between disappearance of PYP images (DAY-PYP) and normalization of LCI level (DAY-LCI). DAY-PYP = 4.4 +/- 0.46 DAY-LCI (n = 13, r = 0.4). Quantitative PYP images were useful for detecting ongoing necrotic myocardium and serum LCI level was useful for estimating destruction of necrotic myocardium.2+ level were useful to study the process of destruction of necrotic myocardium.
15例急性心肌梗死患者在三周内接受了2 - 5次PYP SPECT成像检查。PYP SPECT图像重建后同时包括脊柱图像和心肌图像。通过中央矢状面图像中PYP心肌最大摄取量与PYP脊柱最大摄取量的比值（%PYP）对PYP图像进行定量评估。PYP图像消失定义为%PYP达到50%的那一天。血清肌球蛋白轻链I（LCI）水平恢复正常定义为LCI水平达到2.5 ng/ml的那一天。%PYP持续下降，PYP最大值点保持在同一区域。PYP图像的形状各异且逐渐减小。在前壁梗死的情况下，心尖部PYP摄取持续时间长于基底部摄取。在下壁梗死的情况下，基底部PYP摄取持续时间长于心尖部摄取。PYP图像从出现到消失的平均时间为9±3天。系列血清肌酸激酶同工酶（MB）水平的模式较为简单，然而系列血清LCI水平的相应模式显示出多种类型。从发病到达到峰值水平的平均时间为4.1±1天。LCI水平恢复正常为9.3±2.9天。这表明坏死心肌的破坏过程在每个病例中各不相同。PYP图像消失（DAY - PYP）与LCI水平恢复正常（DAY - LCI）之间存在弱相关性。DAY - PYP = 4.4±0.46 DAY - LCI（n = 13，r = 0.4）。定量PYP图像有助于检测正在发生的坏死心肌，血清LCI水平有助于评估坏死心肌的破坏情况。2+水平有助于研究坏死心肌的破坏过程。
