Li Xiu-Min, Zhang Teng-Fei, Sampson Hugh, Zou Zhong Mei, Beyer Kirsten, Wen Ming-Chun, Schofield Brian
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
Ann Allergy Asthma Immunol. 2004 Aug;93(2 Suppl 1):S35-44. doi: 10.1016/s1081-1206(10)61485-8.
To discuss the potential use of the Chinese herbal formula MSSM-002 in treating asthma based on its effects on a murine model of allergic asthma, immunoregulatory actions on T(H)2 cells in vitro, and the means of standardization for herbal formula quality control.
Information presented at the 2002 American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting International Symposium on Complementary Alternative Medicine in San Antonio, TX.
All presentations from the ACAAI meeting that discussed MSSM-002 were considered for this review.
The Chinese herbal formula MSSM-002 suppressed airway hyperreactivity and eosinophilic inflammation in a murine model of allergic asthma. These effects were comparable to dexamethasone but were not accompanied by the suppression of T(H)1 responses seen with dexamethasone. In vitro studies demonstrated that MSSM-002 significantly decreased antigen-induced T(H)2 cytokine secretion by murine T(H)2 polarized splenocytes and human mucosal T(H)2 cell lines, which in contrast to dexamethasone did not cause apoptosis and was not cytotoxic but was associated with decreased GATA-3 expression. Chromatographic fingerprints of MSSM-002 and evaluation of in vivo actions showed that the quality of several batches of MSSM-002 was consistent.
MSSM-002 has a therapeutic effect on allergic asthma and immunoregulatory actions on established T(H)2 cells and may prove to be of potential clinical benefit to asthma patients.
基于中药复方MSSM - 002对过敏性哮喘小鼠模型的作用、对体外T(H)2细胞的免疫调节作用以及中药复方质量控制的标准化方法，探讨其在治疗哮喘方面的潜在用途。
2002年美国过敏、哮喘与免疫学会（ACAAI）年度科学会议在德克萨斯州圣安东尼奥市举行的补充替代医学国际研讨会所展示的信息。
本综述纳入了ACAAI会议上所有讨论MSSM - 002的报告。
中药复方MSSM - 002可抑制过敏性哮喘小鼠模型的气道高反应性和嗜酸性粒细胞炎症。这些作用与地塞米松相当，但不像地塞米松那样会抑制T(H)1反应。体外研究表明，MSSM - 002可显著降低抗原诱导的小鼠T(H)2极化脾细胞和人黏膜T(H)2细胞系分泌T(H)2细胞因子，与地塞米松不同的是，它不会导致细胞凋亡，也没有细胞毒性，但与GATA - 3表达降低有关。MSSM - 002的色谱指纹图谱及体内作用评估表明，几批MSSM - 002的质量是一致的。
MSSM - 002对过敏性哮喘具有治疗作用，对已建立的T(H)2细胞具有免疫调节作用，可能对哮喘患者具有潜在的临床益处。
