Shou Qiyang, Jin Lu, Lang Jiali, Shan Qiyuan, Ni Zhunan, Cheng Changpei, Li Qinglin, Fu Huiying, Cao Gang
Affiliated Secondary Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.
Front Pharmacol. 2019 Jan 18;9:1531. doi: 10.3389/fphar.2018.01531. eCollection 2018.
Asthma is a chronic airway inflammatory disease, which is characterized by airway remodeling, hyperreactivity and shortness of breath. Paeoniflorin is one of the major active ingredients in Chinese peony, which exerts anti-inflammatory and immune-regulatory effects in multiple diseases. However, it remains unclear whether paeoniflorin treatment can suppress allergic asthma. In this study, we evaluated the effect of paeoniflorin on lung function and airway inflammation in asthmatic mice. These asthmatic Balb/c mice were first sensitized and constructed through ovalbumin (OVA) motivation. Subsequently, we determined the mechanism of action of paeoniflorin in treating allergic asthma through integrated transcriptomic and metabolomic data sets. Our results demonstrated that many genes and metabolites were regulated in the paeoniflorin-treated mice. Moreover, the potential target proteins of paeoniflorin played important roles in fatty acid metabolism, inflammatory response, oxidative stress and local adhesion. Paeoniflorin has a beneficial effect on asthma, which may be achieved through regulating fatty acid metabolism, inflammatory response and the adhesion pathway at system level.
哮喘是一种慢性气道炎症性疾病，其特征为气道重塑、高反应性和呼吸急促。芍药苷是中药芍药的主要活性成分之一，在多种疾病中发挥抗炎和免疫调节作用。然而，芍药苷治疗是否能抑制过敏性哮喘仍不清楚。在本研究中，我们评估了芍药苷对哮喘小鼠肺功能和气道炎症的影响。这些哮喘Balb/c小鼠首先通过卵清蛋白（OVA）激发进行致敏和构建。随后，我们通过整合转录组学和代谢组学数据集确定了芍药苷治疗过敏性哮喘的作用机制。我们的结果表明，在芍药苷治疗的小鼠中，许多基因和代谢物受到调控。此外，芍药苷的潜在靶蛋白在脂肪酸代谢、炎症反应、氧化应激和局部黏附中发挥重要作用。芍药苷对哮喘有有益作用，这可能是通过在系统水平上调节脂肪酸代谢、炎症反应和黏附途径来实现的。
