el-Sawy S A, el-Shafey A M, el-Bahrawy H A
Department of Physiology, Faculty of Medicine, University of Tanta, Tanta, Egypt.
East Mediterr Health J. 2002 Jan;8(1):95-104.
This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans.
本研究评估了联苯双酯对正常肝脏和化学损伤肝脏的作用。给正常大鼠服用联苯双酯对肝酶无显著影响，但在化学损伤大鼠中，肝酶升高水平有显著下降。联苯双酯使正常肝脏和化学损伤肝脏中的还原型谷胱甘肽、谷胱甘肽过氧化物酶和谷胱甘肽还原酶显著增加，丙二醛和葡萄糖-6-磷酸脱氢酶显著减少。组织病理学检查显示，服用联苯双酯后有轻微改善。联苯双酯对肝酶有有益作用，在正常肝脏和化学损伤肝脏中具有显著的抗氧化特性，因此可能在临床上用于治疗人类慢性乙型病毒性肝炎。
