三唑连接的糖基氨基酸和肽的便捷合成
Expedient synthesis of triazole-linked glycosyl amino acids and peptides.
作者信息
Kuijpers Brian H M, Groothuys Stan, Keereweer A Bram R, Quaedflieg Peter J L M, Blaauw Richard H, van Delft Floris L, Rutjes Floris P J T
机构信息
Department of Organic Chemistry, NSRIM, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
出版信息
Org Lett. 2004 Sep 2;6(18):3123-6. doi: 10.1021/ol048841o.
[structure: see text] An expedient, high-yielding synthesis of two types of triazole-linked glycopeptides is described. These novel and stable glycopeptide mimics were prepared via Cu(I)-catalyzed [3 + 2] cycloaddition of either azide-functionalized glycosides and acetylenic amino acids or acetylenic glycosides and azide-containing amino acids.
[结构：见正文] 描述了一种便捷、高产率合成两种类型三唑连接糖肽的方法。这些新型且稳定的糖肽模拟物是通过叠氮官能化糖苷与炔基氨基酸或炔基糖苷与含叠氮氨基酸的铜（I）催化[3 + 2]环加成反应制备的。
Zotero 插件