Biotransformation of quinovic acid glycosides by microbes: direct conversion of the ursane to the oleanane triterpene skeleton by Nocardia sp. NRRL 5646.
作者信息
Cheng Zhi-Hong, Yu Bo-Yang, Cordell Geoffrey A, Qiu Sheng-Xiang
机构信息
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 210038, People 's Republic of China.
出版信息
Org Lett. 2004 Sep 2;6(18):3163-5. doi: 10.1021/ol048787b.
PMID:15330613
Abstract
[reaction: see text] Quinovic acid glycosides were microbially deglycosylated by a Nocardia sp. to their aglycon quinovic acid and its biogenetic counterpart, cincholic acid (3), via an unprecedented carbon skeleton rearrangement involving a methyl group migration. The structures of the metabolites were established by ESI-LC/MS and 2D-NMR techniques.
摘要
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