Synthesis of cladobotryal, CJ16,169, and CJ16,170.
作者信息
Snider Barry B, Che Qinglin
机构信息
Department of Chemistry MS 015, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
出版信息
Org Lett. 2004 Aug 19;6(17):2877-80. doi: 10.1021/ol049130t.
PMID:15330637
Abstract
Condensation of hydroxypyridone 7 with ethyl pyruvate and p-chlorothiophenol, reduction, and cyclization afforded 77% of lactone 6. Protection of the pyridone, acylation of the enolate with tigloyl chloride, and deprotection provided keto lactone 22. Reduction and dehydrative cyclization completed short and efficient syntheses of 2 and 3.
摘要
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