特尔松 A-G，深海真菌中的新吡啶酮生物碱。

Tersone A-G, New Pyridone Alkaloids from the Deep-Sea Fungus .

机构信息

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.

School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.

出版信息

Mar Drugs. 2019 Jul 3;17(7):394. doi: 10.3390/md17070394.

DOI:10.3390/md17070394

PMID:31277263

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6669727/

Abstract

Four phenylfuropyridone racemates, (±)-tersones A-C and E (-, ), one phenylpyridone racemate, (±)-tersone D (), one new pyridine alkaloid, tersone F (), single new phenylfuropyridone, tersone G () and two known analogs and were isolated from the deep-sea fungus . Their structures and absolute configurations were characterized on the basis of comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Moreover, compounds - were evaluated for in vitro antimicrobial and cytotoxic activity. Compounds and exhibited antibacterial activity against with the MIC value of 31.5 μg/mL, while compound showed cytoxic activities against SF-268, MCF-7, HepG-2 and A549 cell lines with IC values of 32.0, 29.5, 39.5 and 33.2 μM, respectively.

摘要

从深海真菌中分离得到四个苯并呋喃并吡啶对映异构体（±）-tersones A-C 和 E（-, ）、一个苯并吡啶对映异构体（±）-tersone D（）、一个新的吡啶生物碱 tersone F（）、一个新的苯并呋喃并吡啶 tersone G（）以及两个已知类似物和。基于综合光谱分析、单晶 X 射线衍射实验和电子圆二色性（ECD）计算，确定了它们的结构和绝对构型。此外，还评估了 - 对体外抗菌和细胞毒性活性的影响。化合物 - 对具有抗菌活性，MIC 值为 31.5 μg/mL，而化合物对 SF-268、MCF-7、HepG-2 和 A549 细胞系的细胞毒性活性分别为 32.0、29.5、39.5 和 33.2 μM。