Arnold Leggy A, Luo Wenchen, Guy R Kiplin
Department of Pharmaceutical Chemistry, University of California-San Francisco, 600 16th Street, San Francisco, California 94143-2280, USA.
Org Lett. 2004 Aug 19;6(17):3005-7. doi: 10.1021/ol0487884.
Historically, general convergent syntheses of medium ring heterocycles have been difficult to develop. Herein, we describe the synthesis of five classes of heterocycles: dihydrodibenzo[b,f]azepine, -oxocine, and -thiocine and dibenzo[b,f]azepine and -oxepine using a strategy of alkylation followed by highly selective intramolecular Heck arylation reaction. The hetero-tricyclic compounds were available in only two steps starting from commercially available starting materials.
从历史上看，中环杂环的一般收敛合成一直难以实现。在此，我们描述了五类杂环的合成：二氢二苯并[b,f]氮杂䓬、-氧杂䓬和-硫杂䓬以及二苯并[b,f]氮杂䓬和-氧杂䓬，采用烷基化策略，随后进行高选择性分子内Heck芳基化反应。这些杂三环化合物只需从市售起始原料开始经过两步即可得到。
