溶液相合成中的聚合物负载碱。2. 弱酸性杂环N-烷基化反应的简便方法。
Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles.
作者信息
Xu W, Mohan R, Morrissey M M
机构信息
Pharmaceuticals Discovery, Berlex Biosciences, Richmond, CA 94804, USA.
出版信息
Bioorg Med Chem Lett. 1998 May 5;8(9):1089-92. doi: 10.1016/s0960-894x(98)00173-5.
PMID:9871713
Abstract
A convenient solution-phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N-alkylation sequences can be carried out in a one-pot process.
摘要
描述了一种使用聚合物负载的超强碱PBEMP进行弱酸性杂环N-烷基化反应的便捷溶液相方法。通过使用该方法，可以在一锅法中进行多步化学选择性N-烷基化序列反应。
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