一种高度汇聚的三环 N-杂环的合成方法，将 Ugi 反应与串联 S(N)2'-Heck 双环化反应偶联。
A highly convergent synthesis of tricyclic N-heterocycles coupling an Ugi reaction with a tandem S(N)2'-Heck double cyclization.
机构信息
Dipartimento di Chimica e Chimica Industriale, Via Docecaneso 31, 16146 Genova, Italy.
出版信息
J Org Chem. 2010 Aug 6;75(15):5134-43. doi: 10.1021/jo100859y.
PMID:20575586
Abstract
A small library of natural product-like compounds has been assembled by coupling an Ugi multicomponent reaction with two postcondensation transformations, carried out in one-pot fashion: a S(N)2' cyclization followed by an intramolecular Heck reaction.
摘要
通过将 Ugi 多组分反应与两种后缩合转化偶联，一锅法完成了一个由天然产物样化合物组成的小库的组装：S(N)2'环化反应，随后是分子内 Heck 反应。
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