Agarwal Mukesh M, Punnose John
Department of Pathology, Faculty of Medicine, UAE University, PO Box 17666, Al Ain, United Arab Emirates.
Expert Opin Investig Drugs. 2004 Sep;13(9):1103-11. doi: 10.1517/13543784.13.9.1103.
Despite four decades of research there is a lack of international consensus on the screening, diagnosis, treatment and follow up of gestational diabetes mellitus (GDM). Currently, GDM is managed by diet modification, exercise and exogenous human insulin. During the last decade, several insulin analogues and oral antihyperglycaemic drugs have revolutionised the management of diabetes mellitus in non-pregnant women. Most of these recent drugs still remain investigational in GDM due to concerns about their safety in pregnancy. This review will focus primarily on the pharmacological treatment of GDM. It will objectively assess the value of these exciting new drugs in pregnancy as they could potentially benefit every woman with GDM.
尽管经过了四十年的研究，但在妊娠糖尿病（GDM）的筛查、诊断、治疗及随访方面仍缺乏国际共识。目前，GDM通过饮食调整、运动和外源性人胰岛素进行管理。在过去十年中，几种胰岛素类似物和口服降糖药彻底改变了非妊娠女性糖尿病的管理方式。由于担心这些药物在孕期的安全性，其中大多数最新药物在GDM中仍处于研究阶段。本综述将主要关注GDM的药物治疗。它将客观评估这些令人兴奋的新药在孕期的价值，因为它们可能会使每位GDM女性受益。
