砷ATP酶外排泵介导亚碲酸盐抗性。
The arsenical ATPase efflux pump mediates tellurite resistance.
作者信息
Turner R J, Hou Y, Weiner J H, Taylor D E
机构信息
Department of Biochemistry, University of Alberta, Edmonton, Canada.
出版信息
J Bacteriol. 1992 May;174(9):3092-4. doi: 10.1128/jb.174.9.3092-3094.1992.
Abstract
The ars operon of the resistance plasmid R773 was found to produce moderate levels of resistance to tellurite. A MIC of 64 micrograms of TeO3(2-) per ml was found for Escherichia coli cells harboring plasmids which contained all three of the structural genes (arsA, arsB, and arsC) of the anion-translocating ATPase. MICs specified by plasmids carrying only one or two structural elements or the cloning vector alone were 2 to 4 micrograms/ml. The rate of TeO3(2-) uptake was found to be on the order of 55% less for cultures containing the resistance plasmids.
摘要
发现抗性质粒R773的ars操纵子对亚碲酸盐产生中等水平的抗性。对于携带包含阴离子转运ATP酶的所有三个结构基因（arsA、arsB和arsC）的质粒的大肠杆菌细胞，发现每毫升的碲酸盐（TeO3(2-)）最小抑菌浓度（MIC）为64微克。仅携带一个或两个结构元件的质粒或单独的克隆载体所指定的MIC为2至4微克/毫升。发现含有抗性质粒的培养物对TeO3(2-)的摄取率降低了约55%。
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