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R因子R773的抗砷操纵子编码的对砷酸盐和亚砷酸盐（锑酸盐）的独立抗性

Separate resistances to arsenate and arsenite (antimonate) encoded by the arsenical resistance operon of R factor R773.

作者信息

Chen C M, Mobley H L, Rosen B P

出版信息

J Bacteriol. 1985 Feb;161(2):758-63. doi: 10.1128/jb.161.2.758-763.1985.

DOI:10.1128/jb.161.2.758-763.1985
PMID:3881408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC214947/
Abstract

The arsenical resistance operon of R factor R773 was analyzed by subcloning and insertional inactivation. The operon was found to have two functional regions, the promoter-proximal region encoding resistance to arsenite and antimonate and the promoter-distal region encoding arsenate resistance. A unique 1.6-kilobase fragment was shown to be sufficient to encode arsenate resistance and produce arsenate extrusion from intact cells.

摘要

通过亚克隆和插入失活分析了R因子R773的抗砷操纵子。发现该操纵子有两个功能区，启动子近端区域编码对亚砷酸盐和锑酸盐的抗性，启动子远端区域编码对砷酸盐的抗性。一个独特的1.6千碱基片段被证明足以编码对砷酸盐的抗性并使完整细胞排出砷酸盐。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/214947/e9a44771e454/jbacter00225-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/214947/84c6aa34d96a/jbacter00225-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/214947/e9a44771e454/jbacter00225-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/214947/84c6aa34d96a/jbacter00225-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5f/214947/e9a44771e454/jbacter00225-0298-a.jpg

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