纤维肌痛综合征患者与健康对照者的正电子发射断层扫描
Positron emission tomography in patients with fibromyalgia syndrome and healthy controls.
作者信息
Yunus Muhammad B, Young Carter S, Saeed S Atezaz, Mountz James M, Aldag Jean C
机构信息
University of Illinois College of Medicine at Peoria, IL 61656, USA.
出版信息
Arthritis Rheum. 2004 Aug 15;51(4):513-8. doi: 10.1002/art.20544.
OBJECTIVE
Abnormal brain findings have previously been described in fibromyalgia syndrome (FMS) by single-photon-emission computed tomography. Our goal was to investigate change in regional cerebral glucose metabolism in people with FMS by positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG).
METHODS
Twelve patients with FMS and no comorbid psychiatric diagnosis and 7 healthy pain-free controls were studied with FDG-PET in a blinded manner. Those with a psychiatric diagnosis were excluded. Brain scans were obtained using a PET scanner. Semiquantitative analysis of regional 18F-FDG uptake was performed in both cortical and subcortical brain structures.
RESULTS
In the resting state, there were no significant differences in 18F-FDG uptake between patients and controls for all brain structures measured.
CONCLUSION
FDG-PET scan findings in FMS were not significantly different from healthy controls. Normal results in our study may be explained by discordance between regional cerebral blood flow and regional cerebral glucose metabolism.
目的
先前通过单光子发射计算机断层扫描已描述了纤维肌痛综合征（FMS）患者存在异常的脑部检查结果。我们的目标是通过使用18F-氟脱氧葡萄糖（FDG）的正电子发射断层扫描（PET）来研究FMS患者局部脑葡萄糖代谢的变化。
方法
对12例无合并精神疾病诊断的FMS患者和7名无疼痛的健康对照者进行了盲法FDG-PET研究。排除有精神疾病诊断的患者。使用PET扫描仪进行脑部扫描。对皮质和皮质下脑结构进行了局部18F-FDG摄取的半定量分析。
结果
在静息状态下，所测量的所有脑结构中，患者与对照者之间的18F-FDG摄取无显著差异。
结论
FMS患者的FDG-PET扫描结果与健康对照者无显著差异。我们研究中的正常结果可能是由于局部脑血流与局部脑葡萄糖代谢之间的不一致所致。
Zotero 插件