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No bias in linkage analysis.

作者信息

Abecasis Goncalo, Cox Nancy, Daly Mark J, Kruglyak Leonid, Laird Nan, Markianos Kyriacos, Patterson Nick

出版信息

Am J Hum Genet. 2004 Oct;75(4):722-3; author reply 723-7. doi: 10.1086/424757.

Abstract
摘要

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本文引用的文献

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Bias toward the null hypothesis in model-free linkage analysis is highly dependent on the test statistic used.
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Inherent bias toward the null hypothesis in conventional multipoint nonparametric linkage analysis.
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Powerful regression-based quantitative-trait linkage analysis of general pedigrees.
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Linkage thresholds for two-stage genome scans.
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Allele-sharing models: LOD scores and accurate linkage tests.
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